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目的 系统评价百令胶囊联合西药治疗慢性肾小球肾炎的临床疗效。方法 计算机检索中国知网、万方、维普、PubMed及Embase等数据库,检索时间从建库至2016年6月,检索相关文献并筛选出百令胶囊联合西药治疗慢性肾小球肾炎的随机对照试验(RCT),并以Jadad量表进行质量评估和提取文献中的原始数据,运用RevMan5.3软件进行Meta分析。结果 共纳入18篇文献,1 274例患者,Meta分析结果显示,试验组治疗后有效率高于对照组[OR=3.26,95% CI(2.35,4.54)](P<0.00001);治疗后试验组24 h尿蛋白定量低于对照组[MD=-0.41,95% CI(-0.45,-0.37)](P<0.00001);治疗后试验组血肌酐低于对照组[MD=-17.27,95% CI(-22.63,-11.9](P<0.00001);治疗后试验组尿素氮低于对照组[MD=-1.60,95% CI(-2.14,-1.06)](P<0.00001)。结论 百令胶囊联合西药治疗慢性肾小球肾炎的临床疗效优于常规的西药治疗,临床安全性好,但纳入该Meta分析的文献质量较低,发表文献存在一定偏倚性,因此,有待于更高质量的随机、多中心、双盲临床试验进行证实。 相似文献
254.
目的 观察益心舒胶囊联合美托洛尔缓释片治疗冠心病室性早搏的临床疗效。方法 将100例冠心病伴室性早搏患者随机分为观察组(益心舒胶囊联合美托洛尔缓释片)与对照组(单用美托洛尔缓释片),疗程均为4周。观察用药前后主要临床症状、24 h动态心电图的变化、QT离散度(QTd)变化。结果 在治疗室性早搏疗效方面,两组室性早博次数均减少(P<0.01),且观察组低于对照组(P<0.05),两组总有效率分别为75.0%、57.1%,两组比较差异有统计学意义(P<0.05);在改善临床症状上,观察组总有效率为62.5%,对照组为55.1%,两组比较差异有统计学意义(P<0.05);在中医症候疗效改善方面,两组患者中医证侯改善疗效的比较差异有统计学意义(P<0.05),观察组证候疗效优于对照组;与对照组相比,观察组QTd、校正QTd明显下降(P<0.01)。结论 益心舒胶囊联合美托洛尔治疗冠心病室性早搏的疗效明显;可以降低QT离散度,抑制恶性心律失常的发生。 相似文献
255.
12种药剂对蛴螬的田间药效评价 总被引:4,自引:0,他引:4
为有效控制花生蛴螬危害,筛选高效、低毒、低残留的农药品种,选用12种不同杀虫剂,采用毒土处理方法进行田间药效试验。试验结果表明,供试的12种药剂中,30%辛硫磷微囊悬浮剂4050 g/hm2、30%毒死蜱微囊悬浮剂2250 g/hm2,对蛴螬防治效果分别为80.85%、78.73%,与3%克百威颗粒剂135 g/hm2、10%二嗪磷颗粒剂750 g/hm2差异不显著,但显著高于其它药剂,其对花生的保果效果分别为81.45%、80.99%,增产幅度分别为15.74%、12.71%,可作为替代高毒产品的理想药剂。 相似文献
256.
XU Li-qun ZHANG Rong-hua XUE Xing-yang WU Xiao-dong FU Shu-ping CAI Yu LIANG Kun CHEN Rui-shen 《园艺学报》2010,26(12):2347-2350
AIM: To investigate the inhibitory effect of Shenci capsule, a Chinese medicine, in combination with cisplatin (DDP) on the tumor growth and angiogenesis in mouse Lewis lung cancer.METHODS: Forty mice with Lewis lung cancer were randomly divided into 4 groups: Shenci capsule group, Shenci capsule in combination with DDP group, DDP group and control group. Shenci capsule, Shenci capsule in combination with DDP,DDP and sodium chloride wene given, respectively. After 21 days, the weight of subcutaneous tumors was measured, and the tumor inhibition rate was calculated. The microvessel density (MVD) and the protein level of vascular endothelial growth factor (VEGF) were detected by immunohistochemical(IHC) staining. The mRNA expression levels of kinase insert domain-containing receptor (KDR) and the receptor of VEGF were detected by FQ-PCR. RESULTS: The tumor growth inhibitory rate in Shenci capsule in combination with DDP group (63.99%) was higher than that in Shenci capsule group, DDP group and control group (P<0.01). The tumor MVD, VEGF protein and KDR mRNA expression level in Shenci capsule in combination with DDP group were lower than those in the above three groups (P<0.01). CONCLUSION: Shenci capsule in combination with DDP have addition or synergistic effects to inhibit the tumor growth and angiogenesis in mouse Lewis lung cancer. Down-regulation of VEGF and its receptor KDR may be one of the mechanisms that combined use of these two drugs for inhibiting angiogenesis. 相似文献
257.
HPLC法测定血塞通胶囊中人参皂苷Rg1、Rb1和三七皂苷R1的含量 总被引:1,自引:0,他引:1
建立血塞通胶囊中人参皂苷含量测定的方法。采用ZORBAXEclipseXDB-C18(4.6×150 mm5,μm)色谱柱;流动相为乙腈∶水(20∶80),流速:1.0 mL/min;梯度洗脱;检测器波长2:03nm。R1在0.3~3.0μg(r=0.999 9,n=6),Rg1在1.28~12.8μg(r=0.999 4,n=6),Rb1在1.32~13.2μg(r=0.999 4,n=6)范围内呈良好的线性关系;平均回收率R1:100.53%,RSD:1.65%;Rg1:97.69%,RSD:2.05%;Rb1:98.08%,RSD:1.59%。该方法简便快捷、分离效果好,可作为产品的质量控制方法。 相似文献
258.
Morphological measurements such as head-capsule (HC) width can be very useful and accessible tools that may be employed for classifying Lepidopteran larval instars according to stage of life history. The availability of such measures is crucial in the management of larval pests, because their control relies upon making accurate assessment of the life history stage at which larvae has reached in various environmental conditions. Such forecasts are then used in order to estimate the timing of emergence for future adult populations. Previous studies investigated the use of head-capsule widths from field larvae of European Grapevine Moth (EGVM), Lobesia botrana Den. and Schiff., to describe the distributions of the five instars during three generations of the insect. The observations were performed in 1998 and 2002 in a vineyard near Bordeaux. The results presented here increase the scope of earlier methods by providing statistical confidence. Our method was calibrated on a large number of individuals (N = 552) issued from our insect culture and uses a nonlinear least-squares parameter estimation to describe the distribution of each larval instar inside each generation. The model was tested on a wild larval population (n = 3007) occurring in our experimental vineyard during two complete years. The instar class ranges and boundaries were characterized with the associated probabilities of misclassification. A final classification statistical model is developed for each instar and each generation. From this study, we conclude that larval HC sizes increase statistically according to the generation of the year, and thus is influenced by grape phenology. 相似文献
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采用HPLC法测定了一通胶囊中番泻苷A的含量。结果表明,番泻苷A进样量在0.062~1.240μg范围内与峰面积积分值具有良好的线性关系,平均加样回收率为97.91%。 相似文献